Abrocitinib Impurity 48 HBr CAS 1622981-00-3(free base)
| CAS No. | 1622981-00-3(free base) |
| Molecular Formula | C11H15N5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Abrocitinib Impurity 48 HBr is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Abrocitinib Impurity 48 HBr (CAS 1622981-00-3(free base)) is a certified pharmaceutical impurity reference standard with the molecular formula C11H15N5HBr and a molecular weight of 298.19 g/mol.
Based on its molecular formula C11H15N5HBr, Abrocitinib Impurity 48 HBr contains a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 298.19 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Abrocitinib Impurity 48 HBr meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H15N5 HBr |
| Molecular Weight | 298.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 5 |
Related Abrocitinib Standards
- Abrocitinib Impurity 56 (CAS 1208319-36-1)
- Abrocitinib (CAS 1622902-68-4)
- Abrocitinib Impurity 16 DiHBr (CAS 1622903-42-7)
- Abrocitinib Related Compound 3 (CAS 1622980-99-7)
- Abrocitinib Impurity 24 (CAS 1622981-01-4)
- Abrocitinib Impurity 23 (CAS 2204275-76-1)
- Abrocitinib Impurity 29 (CAS 2204276-97-9)
- Abrocitinib Impurity 3 (CAS 2204280-33-9)
Recommended Standards
- Ketoconazole EP Impurity C (and enantiomer) (CAS 83374-59-8)
- Menaquinone Impurity 51 (CAS 77898-97-6)
- CAS 2756307-47-6 (CAS 2756307-47-6)
- (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-chloro-4-methoxyphenyl)propanoic acid (CAS 2349340-78-7)
- 1-[(cyclopentylmethyl)sulfanyl]ethan-1-one (CAS 1803561-47-8)
- Cyclopropyl 2-(2,4-dimethylphenyl)ethyl ketone (CAS 898794-64-4)
- (3,5-diaminophenyl)phosphonic acid dihydrochloride (CAS CATO-C3D-262400)
- 3-Chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine (CAS 1019027-76-9)
- 2,3,5-Triiodobenzoic Acid (CAS 88-82-4)
- Semaglutide impurity 44 (CAS CATO-C4X-222644)
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